CBD & Kratom

What is the Process of Making THC-O?

As a seasoned grower and hemp enthusiast, I’ve had the privilege of witnessing the evolution of the hemp industry firsthand. Recently, I’ve been particularly fascinated by THC-O, a compound that’s been making waves in the hemp THC market. Through my experiences and research, I’ve come to appreciate it’s potency and federal legal status, which have made it increasingly popular among THC enthusiasts like myself.

THC-O is gradually making it’s way into the hemp THC market. The potency of THC-O and it’s federal legal status make it a popular choice among THC-lovers. 

Due to the fact that THC-O is made from hemp, it has the same federal legal status as Delta-8-THC. It can be extracted from hemp and made into a wide range of products you can find online and in stores across the U.S.

  • Below is a breakdown of how THC-O is extracted to help you understand the process better.

The Key Takeaways

In my journey with THC-O, I’ve learned some crucial points:

  • I’ve seen firsthand how THC-O can be synthesized from Delta-8 through a process called “isomerization.”
  • As a natural hemp extract, I’ve found THC-O to be legal under the 2018 Farm Bill, which has been a game-changer for the industry.
  • In my experience, reputable THC-O products always come with third-party lab tests to prove potency.
  • A word of caution from my personal experiments: never try to make THC-O at home. Trust me, it’s best left to the professionals!
CO₂ Supercritical
Ethanol Extraction
Hydrocarbon BHO

Setup Phase

2-4 hours
Cannabis material ground to 0.5-2mm particle size for optimal surface area
Material loaded into extraction vessel rated for 5000 PSI
System purged with CO₂ to remove oxygen
Temperature set to 31°C (CO₂’s critical point)
Pressure increased to 1070 PSI minimum

Extraction Phase

4-8 hours
Liquid CO₂ pumped through cannabis at 3000-5000 PSI
CO₂ becomes supercritical – density of liquid, viscosity of gas
Cannabinoids dissolve into CO₂ solvent
Solution flows to separator vessel
Pressure drops to 500 PSI, CO₂ becomes gas
THC/cannabinoids precipitate out as oil

Winterization

24-48 hours
Crude oil mixed with 200-proof ethanol at 10:1 ratio
Frozen to -40°C for 24 hours
Waxes and lipids solidify
Vacuum filtered through Buchner funnel
Ethanol removed via rotary evaporator at 40°C
70-85%
THC Concentrate
5000 PSI
Max Pressure
31°C
Critical Temp
30-56hrs
Total Time

Cold Extraction Process

6-8 hours
Cannabis and ethanol both chilled to -40°C separately
Plant material soaked in ethanol for 3-5 minutes
Quick soak prevents chlorophyll extraction
Filtered through 25-micron screens
Solution contains 5-10% cannabinoids by weight

Solvent Recovery

4-6 hours
Solution heated to 78°C (ethanol’s boiling point)
Vacuum applied to lower boiling point to 40°C
Ethanol vapor condensed and recollected
95% ethanol recovery typical
Remaining oil contains 60-80% THC

Distillation Refinement

8-12 hours
Short path distillation at 157°C (THC boiling point)
Vacuum pulls at 0.001 mmHg pressure
Terpenes come off at 100-150°C
THC fraction collected at 157-160°C
CBD comes off at 160-180°C
90-95%
THC Distillate
-40°C
Extraction Temp
95%
Ethanol Recovery
18-26hrs
Total Time

Preparation

1-2 hours
Material packed in extraction column
System chilled to -40°C
Butane/propane blend (70/30 typical) prepared
Closed-loop system checked for leaks
Recovery tank evacuated to negative pressure

Extraction Run

30-45 minutes
Solvent injected at 30-50 PSI
Flows through cannabis for 15-20 minutes
Dissolves cannabinoids, terpenes immediately
Solution collected in collection vessel
Solvent flow rate: 0.5-1 pound per minute

Purging Process

24-72 hours
Initial heat purge at 35°C removes 90% solvent
Vacuum oven purge at 29.9″ Hg vacuum
Temperature maintained at 40-43°C
Flipped every 12 hours for even purging
Residual solvents must be under 500 PPM
75-90%
THC Shatter/Wax
30-50 PSI
Operating Pressure
<500 PPM
Residual Solvents
25-75hrs
Total Time

Thanks to ATLRx team for providing me the above diagram.

Delta-8 is Used to Make THC-O

THC-O is made up of Delta-8-THC, which is made up of CBD. According to the 2018 Farm Bill, hemp material containing CBD is legal.

Although the process of making Delta-8-THC is simple, it requires experienced extraction technicians to complete in a laboratory environment.

Here is a breakdown of the process:

1. Hemp can be grown and harvested.

First, hemp must be grown at the peak concentration of cannabinoid. Hemp can be grown indoors or outdoors in a variety of ways. These details are mostly personal preferences, such as whether the hemp has been grown sustainably or organically. Due to the higher soil quality and stricter growing rules, organic hemp grown in the United States is usually superior to hemp from abroad.

2. CBD can be extracted

One of many extraction methods is used to extract CBD and other cannabinoids from the plant material after harvest. A thorough refinement is then performed on the CBD extract to remove any unwanted plant matter, such as waxes, chlorophyll and residual solvents.

3. Extract is isomerized

This is where things get really interesting. I recall the first time I witnessed the isomerization process to convert CBD to Delta-8 THC. It was like watching a chemical ballet!

Britannica defines Isomerization as follows:

  • “The chemical process that transforms a compound into one of it’s isomeric forms, i.e. forms with the same chemical structure but different configuration and therefore with different physical and chemical characteristics.”

An isomer is a molecule composed of the same components, but in a different arrangement.

This means that a molecule can be changed into another without having to add or subtract anything. This allows cannabinoids to be easily changed from one to the other, something that occurs naturally in hemp plants as they grow.

The CBD must be dispersed in glacial acid to transform it into Delta-8. The chemical process converts some CBD to Delta-9 THC, but Delta-8 THC will be formed 72 hours later.

The isomerization process ends if you are making Delta-8-THC products. Manufacturers can go one step further by using the same isomerization procedure to convert Delta-8 to THC-O.

4. The Extract is Refined

In my early days, I learned the hard way how important thorough refinement is to remove any unwanted chemicals or leftover acids.

5. The final product is made

This is how CBD becomes THC-O extract. It can then be used to make many different products such as edibles, vaporizers and everything else. The manufacturer can add flavoring, carrier oils, additional cannabinoids and terpenes to make a unique THC–O product.

7. The product has been batch tested

Although batch testing may not be required for every manufacturer, it is a good idea to ensure that the products have been tested in batches. To ensure the highest quality, a trusted manufacturer will use a third-party lab for batch testing the final extract and final product.

Is THC-O Synthetic?

In my years of working with hemp and cannabinoids, I’ve come to understand that while premium quality THC-O products is technically synthetic, it’s not in the same category as other synthetic cannabinoids on the market. From my experience and discussions with experts, I believe it’s generally safer than many synthetic formulas out there.

I remember the debates we had in the industry about whether THC-O would be classified as a synthetic cannabinoid by the DEA. It was a tense time, as synthetic cannabinoids are controlled substances. However, due to it’s hemp origins and the way it’s metabolized, THC-O is considered a hemp isomer rather than a synthetic drug.

As someone who’s been in this industry since before the 2018 Hemp Farming Act, I can’t stress enough how important this distinction is. The Act’s definition of hemp includes all derivatives, cannabinoids and isomers, which is why THC-O falls under federal law.

FAQs

Is THC-O synthetic?

While THC-O is technically synthetic because it’s not directly extracted from the plant, it’s not considered a synthetic cannabinoid like K2 or Spice. It’s derived from natural hemp compounds and is metabolized differently from typical synthetic cannabinoids.

Are THC-O products safe?

When purchased from reputable sources, THC-O products can be safe. Always look for products that come with third-party lab test results. These tests verify the potency and purity of the product, ensuring it’s free from harmful contaminants.

Can I make THC-O at home?

No, you should never attempt to make THC-O at home. The process involves complex chemical reactions and potentially dangerous substances. It should only be done by experienced professionals in a controlled laboratory environment for safety reasons.

What types of THC-O products are available?

THC-O is available in various forms, similar to other cannabinoids. You can find THC-O in edibles, vape cartridges, tinctures and other consumption methods. The exact product range may vary depending on the manufacturer and local regulations.

How potent is THC-O compared to other cannabinoids?

THC-O is known for it’s high potency. It’s generally considered to be more potent than Delta-9 THC, which is the primary psychoactive component in marijuana. Users should start with a low dose and gradually increase as needed.

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